--- title: Research results using ADPKD model from InnoSer description: Request InnoSer’s ADPKD leaflet that contains sample data to learn about the use of the platform for preclinical drug development. image: https://resources.innoserlaboratories.com/hubfs/Imported_Blog_Media/ERA@2x.png --- [Skip to content](https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress#main-content) InnoSer International B.V Open main navigation Close main navigation - [Contact us](https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress#contact) [Contact us](https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress#contact) May 9, 2022 4:36:00 AM # Novel therapeutic molecule for ADPKD presented at the ERA Congress [Casey](https://resources.innoserlaboratories.com/innoser-news/author/casey) Share: [facebook-f icon](http://www.facebook.com/share.php?u=https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress) [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress) [Twitter icon](https://twitter.com/intent/tweet?url=https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress) [pinterest-p icon](http://pinterest.com/pin/create/link/?url=https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress) [envelope icon](mailto:?body=https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress) We look forward to connecting and learning from other life-science companies at events such as the largest annual Nephrology Congress in Europe, the [ERA Congress](https://www.era-online.org/en/paris2022/). Study Director Nephrology Laura Blockken will attend this year’s event, which focuses on recent scientific innovations and important learning features in the clinical field. InnoSer is invested in supporting the preclinical development of new drugs and therapies for ADPKD (Autosomal Dominant Polycystic Kidney Disease). Laura Blockken is delighted to be discussing the promising effects of direct AMP-activated protein kinase (AMPK) activation with a novel molecule, PXL770, in ADPKD models. Previous research has shown the potential role of reduced AMP-activated protein kinase (AMPK) signalling in the regulation of cyst growth – a strong scientific basis for PXL770 use in ADPKD. At the ERA congress, the most recent preclinical evidence for AMPK activation with this novel compound, both in vitro (canine and human models) and in vivo (mouse model), will be introduced and presented as a mini-oral at the congress. ## **An Engineered mouse model for PKD drug development** Within the support provided in drug development, InnoSer offers a unique genetically and phenotypically relevant in vivo [ADPKD mouse model](https://www.innoserlaboratories.com/kidney-diseases/). Our validated conditional (Tamoxifen) kidney-specific Pkd1 knockout mouse (Pkd1-cKO) models are currently available to meet your individual requirements and scientific questions. Amongst the model options, P18 and P10 are well characterized in our pipelines, and P40 presents an even closer similarity to clinical phenotypes. ### Key Readouts: - Body weight (monitored daily) - Kidney weight - Kidney weight to body weight ratio - Urea measurement - Histopathology: cystic index and pathological lesions - Ultrasound imaging to determine kidney volume ### Additional Advantages: - Multiple well-established models - AAALAC accredited facilities - Organ and blood sampling for additional tailored analysis We are thrilled to be attending this high-quality programme and to get to know other life science enthusiasts – we hope you get in touch with Laura at the ERA congress! For more information on our In Vivo ADPKD Mouse Model use the button to request the leaflet including our proprietary data. ### Curious about more information on our ADPKD model? Contact an expert for our PKD leaflet including proprietary data. ## Want to read more? [Blog](https://resources.innoserlaboratories.com/innoser-news/tag/blog), [Nephrology](https://resources.innoserlaboratories.com/innoser-news/tag/nephrology), [laboratory technical support](https://resources.innoserlaboratories.com/innoser-news/tag/laboratory-technical-support), [Events](https://resources.innoserlaboratories.com/innoser-news/tag/events), [ERA congress](https://resources.innoserlaboratories.com/innoser-news/tag/era-congress) ## Related posts [Blog](https://resources.innoserlaboratories.com/innoser-news/tag/blog), [contract breeding](https://resources.innoserlaboratories.com/innoser-news/tag/contract-breeding), [Events](https://resources.innoserlaboratories.com/innoser-news/tag/events), [FELASA Congress](https://resources.innoserlaboratories.com/innoser-news/tag/felasa-congress), [in vivo services](https://resources.innoserlaboratories.com/innoser-news/tag/in-vivo-services), [facility management](https://resources.innoserlaboratories.com/innoser-news/tag/facility-management), [In Vivo](https://resources.innoserlaboratories.com/innoser-news/tag/in-vivo) ## [Facility management and preclinical services discussed at the FELASA Congress](https://resources.innoserlaboratories.com/innoser-news/innoser-offerings/facility-management-and-preclinical-services-discussed-at-the-felasa-congress) [Casey](https://resources.innoserlaboratories.com/innoser-news/author/casey) Jun 5, 2022 3:32:05 PM Animal testing has played a critical role in the development of drugs, enabling us to ultimately... [Read more](https://resources.innoserlaboratories.com/innoser-news/innoser-offerings/facility-management-and-preclinical-services-discussed-at-the-felasa-congress) [![](https://resources.innoserlaboratories.com/hs-fs/hubfs/Imported_Blog_Media/Asset-16@2x.png?height=200&name=Asset-16@2x.png)](https://resources.innoserlaboratories.com/innoser-news/innoser-offerings/get-to-know-our-preclinical-drug-development-services-at-knowledge-for-growth) [Blog](https://resources.innoserlaboratories.com/innoser-news/tag/blog), [laboratory technical support](https://resources.innoserlaboratories.com/innoser-news/tag/laboratory-technical-support), [Events](https://resources.innoserlaboratories.com/innoser-news/tag/events), [in vivo services](https://resources.innoserlaboratories.com/innoser-news/tag/in-vivo-services), [In Vivo](https://resources.innoserlaboratories.com/innoser-news/tag/in-vivo) ## [Get to know our preclinical drug development services at Knowledge for growth](https://resources.innoserlaboratories.com/innoser-news/innoser-offerings/get-to-know-our-preclinical-drug-development-services-at-knowledge-for-growth) [Casey](https://resources.innoserlaboratories.com/innoser-news/author/casey) May 10, 2022 5:00:50 PM We are constantly looking for opportunities to exchange and develop ideas, as they are the... 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[Read more](https://resources.innoserlaboratories.com/innoser-news/events/showcasing-innosers-in-vivo-portfolio-at-the-dutch-life-sciences-conference) facebook-f icon linkedin-in icon Twitter icon instagram icon - Menu Item 1 - Sub-menu Item 1 - Another Item - Sub-menu Item 2 - Menu Item 2 - Yet Another Item - Menu Item 3 - Menu Item 4 --- # InnoSer International B.V 123 Main Street, City, State 11111 Copyright © 2026, ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Casey", "url" : "https://resources.innoserlaboratories.com/innoser-news/author/casey" }, "dateModified" : "2023-07-14T10:13:28.125Z", "datePublished" : "2022-05-09T02:36:00.000Z", "headline" : "Research results using ADPKD model from InnoSer", "image" : [ "https://resources.innoserlaboratories.com/hubfs/Imported_Blog_Media/ERA@2x.png" ], "mainEntityOfPage" : { "@id" : "https://resources.innoserlaboratories.com/innoser-news/events/novel-therapeutic-molecule-for-adpkd-presented-at-the-era-congress", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://resources.innoserlaboratories.com/hubfs/Imported_Blog_Media/Asset-36@3x-1024x155.png" } } } ```